Modulatory Control of Arousal and Affect in Health and Disease

Localisation of the relaxin-family peptide 3 receptor to enteroendocrine cells of the intestine in RXFP3-Cre/tdTomato mice

LJ Fothergill, MT Ringuet, LM Voglsanger, WJN Plange, LC Walker, LR Rivera, AJ Lawrence, AL Gundlach, S Diwakarla, JB Furness, CM Smith

2025-02-01

The relaxin-family peptide 3 receptor (RXFP3) and its native ligand, relaxin-3, are expressed in specific populations of brain neu..

Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain

IM Eraslan, M Egberts-Brugman, JL Read, LM Voglsanger, RM Samarasinghe, L Hamilton, P Dhar, RJ Williams, LC Walker, S Ch'ng, AJ Lawrence, AJ Walker, OM Dean, AL Gundlach, CM Smith

2024-07-01

Relaxin-family peptide 3 receptor (RXFP3) is activated by relaxin-3 in the brain to influence arousal and related functions, such ..

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Mouna Haidar, Kimberly Tin, Cary Zhang, Mohsen Nategh, Joao Covita, Alexander D Wykes, Jake Rogers, Andrew L Gundlach

2019-03-08

Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes ..

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in “floxed-RXFP3” mice impairs spatial memory

M Haidar, G Guèvremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach

2017-05-01

Hippocampus is innervated by γ-aminobutyric acid (GABA) “projection” neurons of the nucleus incertus (NI), including a population ..

Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3/RXFP3 Deficiency

M Haidar, M Lam, BE Chua, CM Smith, AL Gundlach

2016-03-01

Methamphetamine (METH) is a highly addictive psychostimulant, and cessation of use is associated with reduced monoamine signalling..

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

C Zhang, BE Chua, A Yang, F Shabanpoor, MA Hossain, JD Wade, KJ Rosengren, CM Smith, AL Gundlach

2015-10-01

Anxiety disorders are among the most prevalent neuropsychiatric conditions, but their precise aetiology and underlying pathophysio..

Involvement of central relaxin-3 signalling in sodium (salt) appetite

CM Smith, LL Walker, BE Chua, MJ Mckinley, AL Gundlach, DA Denton, AJ Lawrence

2015-09-01

New Findings: What is the central question of this study? Sodium appetite is controlled by conserved neuronal transmitter-receptor..

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

CM Smith, BE Chua, C Zhang, AW Walker, M Haidar, D Hawkes, F Shabanpoor, MA Hossain, JD Wade, KJ Rosengren, AL Gundlach

2014-07-15

Behavioural arousal in mammals is regulated by various interacting central monoamine- and peptide-neurotransmitter/receptor system..

Relaxin-3/RXFP3 networks: An emerging target for the treatment of depression and other neuropsychiatric diseases?

CM Smith, AW Walker, IT Hosken, BE Chua, C Zhang, M Haidar, AL Gundlach

2014-01-01

Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology ..

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

LJ Chan, CM Smith, BE Chua, F Lin, RAD Bathgate, F Separovic, AL Gundlach, MA Hossain, JD Wade

2013-12-06

Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in ..

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

PJ Ryan, E Büchler, F Shabanpoor, MA Hossain, JD Wade, AJ Lawrence, AL Gundlach

2013-05-01

Relaxin-3 is a recently discovered neuropeptide and the results of earlier anatomical and pharmacological studies suggest it plays..